منابع مشابه
long-term t-cell-mediated immunologic memory to hepatitis b vaccine in young adults following neonatal vaccination.
results before boosting, among 176 boosted individuals, 75 (42.6%) had hbsab 10 iu/l and were considered seroprotected. among 101 serosusceptible persons, more than 80% of boosted individuals showed more than twofold increase in cytokines concentration, which meant positive hbsag-specific cell-mediated immunity. mcl of both cytokines after boosting in giv were decreased more than twofold, possi...
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Background: The effectiveness of T cell vaccination has been demonstrated in a variety of animal models of both induced and spontaneous autoimmune diseases. Objective: The purpose of this study was to test the T cell vaccination protocol to treat and prevent collagen induced arthritis (CIA) in a rheumatoid arthritis model. Methods: CIA was induced by an intradermal injection of an artheritogen ...
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Here we review T cell vaccination (TCV), a cell-based, generic approach to immune regulation. We describe TCV clinical trials in multiple sclerosis and other autoimmune diseases; we analyze the immune regulatory mechanisms activated by TCV; we examine the potential of public T cells as TCV mediators, and we discuss the physiology of immune regulation in the light of TCV.
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Immunological memory is a key feature of adaptive immunity. It provides the organism with long-lived and robust protection against infection. In organ transplantation, memory T cells pose a significant threat by causing allograft rejection that is generally resistant to immunosuppressive therapy. Therefore, a more thorough understanding of memory T cell biology is needed to improve the survival...
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CD4+ T helper memory (Thmem) cells influence both natural and vaccine-boosted immunity, but mechanisms for their maintenance remain unclear. Pro-survival signals from the common gamma-chain cytokines, in particular IL-7, appear important. Previously we showed in healthy volunteers that a booster vaccination with tetanus toxoid (TT) expanded peripheral blood TT-specific Thmem cells as expected, ...
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ژورنال
عنوان ژورنال: Vaccines
سال: 2018
ISSN: 2076-393X
DOI: 10.3390/vaccines6040084